Research Highlights
1972 - 1989
on Boswellin from 1972 to 1989

Studies on the metabolism of glycosaminoglycans under the influence of new herbal anti-inflammatory agents
Reddy GK, Chandrakasan G, Dhar SC
Biochem Pharmacol 1989 Oct 15; 38(20); 3527-3534

The present study focused on the in-vivo effect of an herbal based, non-steroidal anti-inflammatory product boswellic acid on glycosaminoglycan metabolism. Glycosaminoglycan degradation was found to be markedly reduced in all drug-treated animals as compared to controls. Significance of boswellic acids is discussed in the light of changes in the glycosaminoglycan metabolism.

Anti-arthritic activity of boswellic acids in bovine serum albumin (BSA) induced arthritis
Sharma ML, Bani S, Singh GB
Int J Immunopharmacol 1989 11(6); 647-652

The authors focused on the effect of boswellic acids on bovine serum albumin (BSA) induced arthritis in rabbits. The local injection of boswellic acids (5, 10 and 20 mg) into the knee 15 min prior to BSA challenge also reduced the infiltration of leucocytes. The effect of boswellic acids on bovine serum albumin induced arthritis in rabbits was studied. Oral administration of boswellic acids (25, 50 and 100 mg/kg/day) significantly reduced the population of leucocytes in a BSA-injected knee. The results proved that the leucocyte-inhibitory activity of boswellic acids was not due to its cytotoxic effect.

Chemistry and Pharmacology of the gum resin of B. serrata.
Gupta, V.N., Yadav, D.S., Jain, M.P., Atal, C.K.
Indian Drugs 1987 24(5), 221-231

Annual Report, Regional Research Laboratory, Jammu, India (1987-88), pp 1-2

Urinary excretion of connective tissue metabolites under the influence of a new non-steroidal anti-inflammatory agent in adjuvant induced arthritis
Reddy GK, Dhar SC, Singh GB
Agents Actions 1987 Oct; 22(1-2); 99-105

The authors investigated the therapeutic effect of boswellic acids in adjuvant induced arthritics in relation to urinary excretion of connective tissue metabolites. The elevated levels of urinary hydroxyproline, hexosamine and uronic acid in arthritic animals were found to be decreased in acute phase and significantly decreased in the chronic phase of the disease. Results indicate that anti inflammatory drugs could offer protection against adjuvant induced arthritis.

Effect of a new non-steroidal anti-inflammatory agent on lysosomal stability in adjuvant induced arthritis
Reddy GK, Dhar SC
Ital J Biochem 1987 Jul-Aug; 36(4); 205-217

The present study explored the effect of non-steroidal anti-inflammatory agents on lysosomal stability. Adjuvant arthritic animals showed a significant increase in beta-glucouronidase activity. The increased rate of the release of beta-gluco uronidase from lysosome-rich fraction clearly suggested that arthritic syndrome caused decreased stability of the lysosomes. Administration of boswellic acids to arthritic animals was found to increase the lysosomal stability. Of the two anti-inflammatory agents tested, salai-guggal was found to afford more therapeutic value.

Kinetic mechanism of guinea pig neutrophil 5-lipoxygenase
Aharony, D., and Stein, R.L
J. Biol. Chem. 1986 261, 11512-11519

Authors in this report investigated the kinetic mechanism of guinea pig neutrophil 5-lipoxygenase by spectrophotometric assay. Progress curves for reactions with arachidonic acid and eicosapentaenoic acid were characterized. Oxygenation of eicosapentaenoic acid in the presence of Ca2+ and ATP occurs with similar kinetics, except for significantly less substrate inhibition. This is the first report suggesting a kinetic mechanism for 5-lipoxygenase, which accounts for substrate inhibition, regulated by Ca2+, and ATP and substrate specificity.

Derivatives of boswellic acids
el-Khadem H., el-Shafei ZM., el-Sekeily MA., Rahman MM
Planta Med. 1972 Sep; 22(2); 157-159

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